ABSTRACT
This article reports the investigation of the effect of carvedilol (Car) on T-type calcium current (I(Ca,T)) of noninfarcted ventricular myocytes in rabbit models of healed myocardial infarction (HMI). Rabbits with left anterior descending artery ligation were prepared and allowed to recover for 8 weeks, as HMI group. Animals undergoing an identical surgical procedure without coronary ligation were served as the sham-operated group (sham group). Whole cell voltage-clamp techniques were used to measure and compare currents in cells from the different groups. Noting that I(Ca,T) density in HMI cells increased markedly to -2.36 +/- 0.12 pA/pF (at -30 mV) compared with cells of sham, where little I(Ca,T) (-0.35 +/- 0.02 pA/pF) was observed. Meanwhile, further analysis revealed a significant hyperpolarizing shift of steady-state activation curve of I(Ca,T) in HMI cells, where the time constants of deactivation were prolonged and the time of recovery from inactivation was shortened. Finally, the amplitude of I(Ca,T) was increased. Carvedilol (1 micromol x L(-1)) was found to decrease the amplitude of I(Ca,T) to -1.38 +/- 0.07 pA/pF through inhibiting process of I(Ca,T) activation. Furthermore, carvedilol delayed recovery from inactivation of I(Ca,T) and shortened the time constants of deactivation in HMI cells. This study suggested that the application of carvedilol in HMI cells contributes to the dynamic changes in I(Ca,T) and may account for reduction of incidence of arrhythmia after myocardial infarction.
ABSTRACT
@#Objective To investigate the balance function of the knee osteoarthritis (KOA) patients and the clinical value about static fallindex test and dynamic fall index test for the patients with knee osteoarthritis. Methods The osteoarthritis patients without knee pain (controlgroup, n=30) were tested with postural stability (PS), limits of stability (LOS), dynamic fall index (DFI) and static fall index (SFI). Theosteoarthritis patients with knee pain (treatment group, n=30) accepted 10 times of diclofenac diethylamine emulge imported by pulsed ultrasoundand 6 times of massage therapy. They were also tested with above four balance tests and Western Ontario and McMaster UniversitiesOsteoarthritis Index (WOMAC) before and after treatments. Results There was significant difference in overall of PS, anterior/posterior indexand medial lateral index (P<0.05) between the control group and the treatment group before treatments, and there was very significantdifference in time to complete LOS, overall of LOS and DFI (P<0.01); but there was no significant difference in SFI (P<0.05). There wassignificant difference in WOMAC scores, overall of PS, anterior/posterior index, time to complete LOS, overall of LOS and DFI (P<0.05) inthe treatment group before and after treatments, but there was no significant difference in medial lateral index and SFI (P<0.05). ConclusionCompared with osteoarthritis patients without knee pain, KOA patients with knee pain are in poorer balance function and greater fall risk.After effective treatments, the balance function and fall risk of the KOA patients may significantly improve. Compared with SFI test, theDFI test is more sensitive to the improvement of balance function of the KOA patients.
ABSTRACT
@#Objective To explore the relationship between the somatosensory evoked potential (SEP) diversification during operation and the short term outcome of ossification of posterior longitudinal ligament (OPLL) of cervical spine. Methods 70 OPLL inpatients from February 2008 to February 2011were included in this study. All patients received anterior cervical operation. According to the diversification of the SEP during surgery, the patients were divided into 2 groups. The preoperative and postoperative JOA scores of the OPLL patients were collected. Results There were 35 patients in the SEP no change group and 30 in SEP improved group. There was no difference in the preoperative JOA scores between them (P>0.05), but was significantly different in the postoperative JOA scores (P>0.05). Conclusion There is some relationship between the SEP diversification during operation and the short term outcome of OPLL of cervical spine.
ABSTRACT
@#Objective To explore the factors related with the quality of life in the elderly patients with knee osteoarthritis. Methods 92elderly patients with knee osteoarthritis were tested with short-form 36 health survey scale (SF-36), visual analogue pain scale (VAS), 5times' movement of sit-to-stand, 10 m walking speed, 3 m timed-up and walking test. At the same time, the radiological grades of knees andthe total amount of chronic diseases were collected. Results The VAS of knee pain, the course of knee osteoarthritis, the total amount ofchronic diseases and 10-m walking speed were related with SF-36 score (P<0.01). Conclusion Knee pain, course of knee osteoarthritis, totalamount of chronic diseases and walking ability are related with the quality of life in the elderly patients with knee osteoarthritis, especiallyfor knee pain.
ABSTRACT
@#ObjectiveTo observe the effect of acupoint rotating magnetic field(RMF) therapy on the pain and Fricton's index in patients with temporomandibular disorders(TMD).Methods65 TMD patients, who met the inclusive criteria, were randomly divided into two groups: the acupoint rotating magnetic therapy group(treatment group, n=35) and the ultrashortwave diathermy group (control group, n=30). The treatment group received XZC-A rotating magnetic field therapy at the acupoints in the affected side, including Xiaguan(ST7), Tinggong(SI19), Jiache(ST6), Yifeng(SJ17) and Ashi, 10 minutes for each acupiont, the course of treatment was performed twice daily for 10 days. The control group was treated with ultrashortwave diathermy for 15～20 min once daily, and considered 10 days as a course of treatment. The patients were evaluated before and after the treatment through Visual Analogue Scale (VAS) and Fricton's Craniomandibular Index(CMI) respectively.ResultsThe values of VAS and CMI in the both groups significantly reduced after a course of treatment respectively (P<0-05), and there were significant differences regarding the post-therapy values of VAS and CMI (P<0-05) between two groups. The values of VAS and CMI in the treatment group reduced more significantly than those in the control group(P<0-05).ConclusionAcupoint rotating magnetic field therapy can relieve the pain and improve the functions of TMD in patients with temporomandibular joint disorder.
ABSTRACT
@#ObjectiveTo determine the value of the five-times sit-to-stand test (FTSST) on assessment of physical performance for older people.Methods65 volunteers participated in this study. 21 of them were evaluated the FTSST twice by the same raters within one week. Test-retest reliability assessed using intraclass correlation coefficients (ICC). 65 volunteers were tested for the FTSST, the Timed "up & go" test(TUGT) and the strength of lower limbs. The Pearson's correlation (r) and stepwise regression analysis was used to examine the relationship between these variables and the FTSST time.ResultsThe FTSST showed good test-retest reliability(ICC=0-91, 95%CI:0-79～0-96). The TUGT, the strength of lower limbs and age were significantly related to the FTSST time (P<0-05). The strength of lower limbs was important clinical factor to consider in determining the FTSST time.ConclusionThe FTSST showed good test-retest reliability and can reflect the physical functional status of older people.
ABSTRACT
@#ObjectiveTo apply the physical function test in evaluating the lower extremity muscle strength in patients with knee osteoarthritis. Methods33 patients with knee osteoarthritis who had radiological diagnosis and clinical symptoms were tested with 5 times sit-to-stand, 10 m walking speed, timed up and go test and isokinetic muscle strength. ResultsThere were very high correlation among 5 times sit-to-stand, 10 m walking speed and timed up and go (P<0.001). The lower extremity extensor muscle strength correlated with 5 times sit-to-stand, 10 m walking speed and timed up and go respectively (P<0.05). Conclusion5 times sit-to-stand test reflects the walking ability and the lower extremity muscle strength in patients with knee osteoarthritis, which can be used as a kind of assessment for knee osteoarthritis.
ABSTRACT
@# ObjectiveTo investigate the relationship of lower extremity muscle strength and the pain or physical function in patients with knee osteoarthritis. Methods25 patients with knee osteoarthritis diagnosed with have radiological and clinical data were assessed with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and isokinetic muscle strength testing. ResultsThe lower extremity extensor muscle strength correlated with WOMAC pain scores, WOMAC activity of daily life scores, and WOMAC total scores （P<0.05）. ConclusionThe lower extremity extensor muscle strength correlated with the pain and physical function in patients with knee osteoarthritis.
ABSTRACT
@#ObjectiveTo apply the physical function test in evaluating the lower extremity muscle strength in patients with knee osteoarthritis. Methods33 patients with knee osteoarthritis who had radiological diagnosis and clinical symptoms were tested with 5 times sit-to-stand, 10 m walking speed, timed up and go test and isokinetic muscle strength. ResultsThere were very high correlation among 5 times sit-to-stand, 10 m walking speed and timed up and go (P<0.001). The lower extremity extensor muscle strength correlated with 5 times sit-to-stand, 10 m walking speed and timed up and go respectively (P<0.05). Conclusion5 times sit-to-stand test reflects the walking ability and the lower extremity muscle strength in patients with knee osteoarthritis, which can be used as a kind of assessment for knee osteoarthritis.
ABSTRACT
@#ObjectiveTo determine the test-retest reliability of isometric muscle strength measurement for the lower limb with functional squat system （FSS） in elderly people. Methods20 elderly participants were measured the isometric muscle strength in 5 s of each lower limb with FSS, and retested a week later. The maximal voluntary contraction and the average strength of each lower limb were recorded. ResultsThe intraclass correlation coefficient were 0.77～0.88 (P<0.01). ConclusionIsometric muscle strength measurement of the lower limb with FSS shows acceptable test-retest reliability in elderly.
ABSTRACT
@#ObjectiveTo investigate the age-related changes in grip strength of the elderly men and compare with the norms of overseas. Methods112 subjects were divided into six groups: 65～69 years old, 70～74 years old, 75～79 years old, 80～84 years old, 85～89 years old, and 90～95 years old. The grip strength was measured with Jamar dynamometer. ResultsThe grip strength of both sides were significantly moderate negative correlated to age (r=-0.681 and -0.68, P<0.001) and stepwise regression analysis showed the age was important clinical factor to consider in determining grip strength in the elderly men （R2=0.468, F=47.951, P＜0.001). The grip strength was declined significantly during the 75～79 and 85～89 years old. ConclusionGrip strength had declined in the elderly men and these losses were significantly related to age. The highest loss in men was in the age over 75. The norms of grip strength overseas were not applicable to Chinese older adults.
ABSTRACT
@# ObjectiveTo examine the test-retest reliability and measurement error in using a Jamar dynamometer to determine grip strength for elder men. Methods40 elder men with a mean age of 82 years old volunteered to participate in this study. The grip strength was administered twice using a Jamar dynamometer by specially trained testers; subjects were re-tested at the same time of day a week later by the same testers. ResultsThe infraclass correlation coefficient（ICC） was 0.99. The standard error of measurement (SEM and SEM%) were 1.18～1.69 and 4.11%～6.41%. The smallest real difference (SRD and SRD%) were 3.27～4.68 and 11.39%～17.75%. The Bland-Altman analysis revealed no systematic errors between test and retest. ConclusionThe Jamar dynamometer is reliable and with acceptable measurement errors to determine grip strength for elder men.
ABSTRACT
@#Objective To observe the clinical effect of manipulation combined with physical therapy on middle-elderly knee osteoarthritis (KOA).Methods 32 KOA patients (49 knees) were treated with manual operation, such as manipulation relaxing the end of quadriceps, triceps, surae and other manipulation method for knee joint and combined with physical therapy.Results 11 cases (18 knees) were clinical curative, 16 cases (23 knees) had good effective, 5 cases (knees) had effective. The good effective rate was 84%.Conclusion Manipulation combined with physical therapy is effective on middl-elderly KOA patients.
ABSTRACT
@# Objective To observe the therapeutic effect of warm magnetic field combined with medium frequency electric current on lumbar intervertebral disc protrusion of old patients.Methods By retrospective analysis, 120 old patients with lumbar intervertebral disc protrusion were divided into the therapeutical group (treated with warm magnetic field combined with medium frequency electric current) and control group (treated with ultrashort wave combined with medium frequency electric current), and therapeutic effects of two groups were compared.Results There was no significant difference between the therapeutic effects of two groups ( P>0.05).Conclusion Warm magnetic field combined with medium frequency electric current is same effect as ultrashort wave combined with medium frequency electric current on lumbar intervertebral disc protrusion of old patients.
ABSTRACT
@#Objective To study the test-retest reliability of grip strength assessment in the bed-ridden elders above 80 years old. Methods The left and right grip strength of 20 patients who were bed-ridden for more than 1 year, older than 80 years were measured on the lying position with the JAMAR Hand Dynamometer, and they were measured again in the same way by the same conner a week later. Results The intraclass correlation coefficient were 0.985 and 0.970 in the grip strength of left and right hands, respectively. Conclusion The assessment of grip strength showed good test-retest reliability in the bed-ridden elders above 80.
ABSTRACT
@#Objective To investigate the effect of different dosage of pulsed magnetic field on expression of platelet-derived growth factor-A (PDGF-A) in rabbits with carotid atherosclerosis after carotid endarterectomy (CEA). Methods Carotid atherosclerosis were modeled in 50 New Zealand rabbits with air-drying lesion combined with high fat feed. All animals were treated with double side carotid endarterectomy after 2 months, and were randomly divided 3 groups: 0.6 T group, 1.0 T group and the blank control. The expression of platelet-derived growth factor-A were detected with immunohistochemistry 1 month, 2 months and 3 months after CEA. Results The expression of PDGF-A in treated groups were lower significantly than that in controls (P<0.05) 2 month after CEA, and it was the lowest in 1.0 T group, lower in 0.6 T group 3 month after CEA. Conclusion The pulsed magnetic field therapy can decrease the expression of PDGF-A, which might be helpful to prevent the carotid from restenosis.
ABSTRACT
@#Objective To observe the effect of manipulation treatment on headache induced by pure pillow linea nuchae inferior adhesion muscle spasm.Methods 36 headache patients caused by pure pillow linea nuchae inferior adhesion muscle spasm were treated by manipulate the methods of finger press and palm root circle press in base on fixing Ash points according to the symptoms and physical signs.Results After 5 to 10 times by manipulation,of 36 patients,25 cases were recovery,10 cases were excellent,1 case was effective,and the excellence effective rate was 97.22%.Conclusion The manipulation treatment is effect on headache induced by pure pillow linea nuchae inferior adhesion muscle spasm;the curative effect is satisfactory and stable.
ABSTRACT
@#Objective To investigate the correlation between anthropometric parameters and grip strength in healthy young adults.Methods The measurement data of 32 healthy young adult subjects(all right-hand dominant)including the age,height,weight,forearm length,forearm circumference,hand length,hand width and palm thickness were collected.The grip strength of right hand of all subjects was measured with dynamometer the G100 spring-grip dumbbells.Results The human measurement data were all significantly related(r=0.479-0.754,P<0.01)with grip strength except age(r=-0.009,P>0.05).In addition,stepwise linear regression models indicated that the hand length and hand width were the main predictor of grip strength(R2=0.723).Conclusion Grip strength is significantly related to anthropometric parameters of healthy young adults.The hand length and hand width are independent predictor of grip strength.
ABSTRACT
@#Objective To determine the difference between two standardized grip strength test,the American Society of Hand Therapists(ASHT)recommended and the Chinese National Physical Fitness Evaluation Standard(CNPFES)recommended.Methods 32 healthy young adult,right-hand dominant subjects were measured with their grip strength under the both methods.Results The measurement of grip strength using methods the ASHT recommended was smaller than that of the CNPFES(P<0.05),for all their left and right hand.Conclusion The measures of grip strength are different between ASHT and CNPFES standard.It is important to keep the testing conditions while measuring grip strength,and ASHT is suggested.
ABSTRACT
@# Objective To observe the effect of multidisciplinary rehabilitation on activity of daily living (ADL) and injured nerve function of old stroke patients.Methods 78 old stroke patients were randomly divided into the simple rehabilitation group (36 cases) and multidisciplinary rehabilitation group (42 cases). The patients of the simple rehabilitation group were treated with Bobath method only, those of the multidisciplinary rehabilitation group were added with acupuncture and Chinese herbs. The treatment course of two groups was 6 weeks. All patients in two groups were assessed with Modified Brathel Index (MBI) for ADL before treatment and every week after treatment and the evaluation of National Institute of Health Stroke Scale (NIHSS) was also performed for injured nerve function at same times.Results After 3 weeks treatment, the scores of MBI and NIHSS of all patients improved, but there was no significant difference compared with that before treatment ( P>0.05). After 6 weeks treatment, the NIHSS scores of the patients in the multidisciplinary rehabilitation group was significant superior to that before treatment ( P<0.05), the MBI scores was also superior to that before treatment ( P<0.01); while, the NIHSS and MBI scores of the patients in the simple rehabilitation group also improved compared with that before treatment, but no significant difference ( P>0.05).Conclusion Both multidisciplinary rehabilitation and simple rehabilitation are all effect on ADL and injured nerve function of old stroke patients, but the effect of multidisciplinary rehabilitation is superior to that of simple rehabilitation (using Bobath method only).